Publications

Core Technologies

What we do.

Y. Afshar, J. Dong, P. Zhao, L. Li, S. Wang, R. Zhang, C. Zhang, O. Yin, C. Han, B. Einerson, T. Gonzalez, H. Zhang, A. Zhou, Z. Yang, S.-J. Chou, N. Sun, J. Cheng, H. Zhu, J. Wang, T.X Zhang, Y.-T. Lee, J. Wang, P.-C. Teng, P. Yang, D. Qi, M. Zhao, M.-S. Sim, R. Zhe, J. Goldstein, J. Williams, X. Wang, Q. Zhang, L. Platt, C. Zou, M. Pisarska, H.-R. Tseng, Y. Zhu (2021) Circulating Trophoblast Cell Clusters for Early Detection of Placenta Accreta Spectrum Disorders. Nat. Commun., 12(1): 1-14. PMCID: PMC8333096
Y.‐T. Lee, N. Sun, M. Kim, J. Wang, B. Tran, R. Zhang, D. Qi, C. Zhang, P.‐J. Chen, S. Sadeghi, R. Finn, S. Saab, S.‐H. Han, R. Busuttil, R. Pei, Y. Zhu, H.‐R. Tseng, S. You, J. Yang, V. Agopian (2021) Circulating Tumor Cell‐Based mRNA Scoring System for Prognostication of Hepatocellular Carcinoma‐Translating HCC Tissue‐based mRNA Profiling into a Non‐invasive Setting. Liver Transpl., 1-15. PMID: 34664394
J. Wang, K. Cavassani, P.-C. Teng, J.-F. Chen, Y. Jan, G. Chu, Y.-T. Lee, A. Gao, D. Di Vizio, L. Chung, S. You, Y. Zhu, M. Freeman, A. Rogatko, J. Yang, H.-R. Tseng, E. Posadas (2021) A Morphological Subset of Circulating Tumor Cells in Advanced Prostate Cancer Reveals a Potential Biomarker for Clinical Outcomes. J Clin Oncol, 39(15_suppl): e17008-e17008.
J. Wang, K. Cavassani, P.-C. Teng, J.-F. Chen, Y. Jan, G. Chu, Y.-T. Lee, A. Gao, D. Di Vizio, L. Chung, S. You, Y. Zhu, M. Freeman, A. Rogatko, J. Yang, H.-R. Tseng, E. Posadas (2021) Nuclear Size of Circulating Tumor Cells in Advanced Prostate Cancer to Reveal a Potential Biomarker for Clinical Outcomes and Androgen Receptor Indifference. J Clin Oncol, 39(6_suppl): 167-167.
N. Sun, Y.‐T. Lee, M. Kim, J. Wang, C. Zhang, P.‐C. Teng, D. Qi, R. Zhang, B. Tran, Y. Lee, J. Ye, J. Palomique, N. Nissen, S.‐H. Han, S. Sadeghi, R. Finn, S. Saab, R. Busuttil, E. Posadas, L. Liang, R. Pei, J. Yang, S. You, V. Agopian, H.‐R. Tseng, Y. Zhu (2021) Covalent Chemistry‐Mediated Multimarker Purification of Circulating Tumor Cells Enables Noninvasive Detection of Molecular Signatures of Hepatocellular Carcinoma. Adv. Mater. Technol., 6, 2001056-1-11. PMCID: PMC8240468
J. Ahn, P.‐C. Teng, P.‐J. Chen, E. Posadas, H.‐R. Tseng, S. Lu, J. Yang (2021) Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma. Hepatology, 73 (1): 422-436. PMCID: PMC8183673
Y.J. Jan, J. Yoon, J.-F. Chen, P.-C. Teng, N. Yao, S. Cheng, A. Lozano, C.-Y. Chu, H. Chung, Y.-T. Lu, P.-J. Chen, J.J. Wang, Y.-T. Lee, Y. Zhu, B.S. Knudsen, F.Y. Feng, I.P. Garraway, A.C. Gao, L.W.K. Chung, M.R. Freeman, S. You, H.-R. Tseng, E.M. Posadas (2019) A Circulating Tumor Cell-RNA Assay for Assessment of Androgen Receptor Signaling Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer. Theranostics; 9: In press. PMCID: PMC6568173
J. Dong, R.Y. Zhang, N. Sun, M. Smalley, Z. Wu, A. Zhou, S.J. Chou, Y.J. Jan, P. Yang, L. Bao, D. Qi, X. Tang, P. Tseng, Y. Hua, D. Xu, R. Kao, M. Meng, X. Zheng, Y. Liu, T. Vagner, X. Chai, D. Zhou, M. Li, S.H. Chiou, G. Zheng, D. Di Vizio, V.G. Agopian, E.M. Posadas, S.J. Jonas, S.P. Ju, P.S. Weiss, M. Zhao, H.-R. Tseng, and Y. Zhu (2019) Bio-Inspired NanoVilli Chips for Enhanced Capture of Tumor-Derived Extracellular Vesicles: Toward Non-Invasive Detection of Gene Alterations in Non-Small Cell Lung Cancer. ACS Appl. Mater. Interfaces; 11: In press. PMCID: PMC6545291
M. Hou, Y. Zheng, Z. Ding, S. He, M. Xu, X. Chen, H. Zheng, C. Sun, W. Jiang, H. Wang, H. Shen, Y. Zhang, J. Liu, S. Sun, N. Jiang, Y. Cui, Y. Sun, Y. Chen, J. Cao, C. Wang, M. Li, Y. Zhang, J. Wang, M. Lin, Z. Ke (2019) The Role of a Semi-Automated NanoVelcro System in Capturing Circulating Tumor Cells and Evaluating Their Prognostic Value for Gestational Choriocarcinoma. Biomater. Sci.; 2019, 7, 1200-1210. In Press. PMID: 30656300
W. He, M. Hou, H. Zhang, C. Zeng, S. He, X. Chen, M. Xu, C. Sun, W. Jiang, H. Wang, H. Shen, Y. Zhang, J. Liu, S. Sun, N. Jiang, Y. Cui, Y. Sun, Y. Chen, J. Cao, C. Wang, M. Li, Y. Xhang, L. Wang, J. Wang, M. Lin, Z. Ke (2018) Clinical significanve of circulating tumor cells in predicting disease progression and chemotherapy resistance in patients with gestational choriocarcinoma. International Journal of Cancer; 144(6), 1241-1431: In Press. PMCID: PMC658745
M. Reis-Sobreiro, J.-F. Chen, T. Novitskaya, S. You, S. Morley, K. Steadman, N.K. Gill, A. Eskaros, M. Rotinen, C.-Y. Chu, L.W.K. Chung, H. Tanaka, W. Yang, B.S. Knudsen, H.-R. Tseng, A.C. Rowat, E.M. Posadas, A. Zijlstra, D. Di Vizio, M.R. Freeman (2018) Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential, Cancer Research, Cancer Res; 78(21); 6086–97.
A.F. Salem, S. Wang, S. Billet, J.-F. Chen, P. Udompholkul, L. Gambini, C. Baggio, H.-R. Tseng, E.M. Posadas, N.A. Bhowmick, M. Pellecchia (2018) Reduction of Circulating Cancer Cells and Metastases in Breast-Cancer Models by a Potent EphA2-Agonistic Peptide–Drug Conjugate, J. Med. Chem., 61 (5), 2052–2061. PMCID: PMC5907794
C.M. Court, S. Hou, P. Winograd, N.H. Segel, Q. Wilda Li, Y. Zhu, S. Sadeghi, R.S. Finn, E. Ganapathy, M. Song, S.W. French, B. Naini, S. Sho, F.M. Kaldas, R.W. Busuttil, J.S. Tomlinson, H.-R. Tseng, V.G. Agopian (2018) A Novel Multimarker Assay for the Phenotypic Profiling of Circulating Tumor Cells in Hepatocellular Carcinoma, Liver Transplantation, 24(7), 946-960. PMCID: PMC6097911
Y.J. Jan, J.-F. Chen, Y. Zhu, Y.-T. Lu, S.H. Chen, H. Chung, M. Smalley, Y.-W. Huang, Ji. Dong, L.-C. Chen, H.-H. Yu, J.S. Tomlinson, Hou, V. G. Agopian, E. M. Posadas, H.-R. Tseng (2018) NanoVelcro Rare-Cell Assays for Detection and Characterization of Circulating Tumor Cells, Adv. Drug Delivery Rev. 125: 78-93. PMCID: PMC5993593
C.M. Court, J.S. Ankeny, S. Sho, P. Winograd, S. Hou, M. Song, Z.A. Wainberg, M.D. Girgis, T.G. Graeber, V.G. Agopian, H.-R. Tseng, J.S. Tomlinson (2018) Circulating Tumor Cells Predict Occult Metastatic Disease and Prognosis in Pancreatic Cancer, Ann. Surg. Oncol. 25(X): In press. PMCID: PMC5896564
M.-Y. Shen, J.-F. Chen, C.-H. Luo, S. Lee, C.-H. Li, Y.-L. Yang, Y.-H. Tsai, B.-C. Ho, L.-R. Bao, T.-J. Lee, Y.J. Jan, Y. Zhu, S. Cheng, F.Y. Feng, P. Chen, S. Hou., V. Agopian., Y.-S. Hsiao, H.-R. Tseng, E.M. Posadas, H. Yu (2018) Glycan Stimulation Enables Purification of Prostate Cancer Circulating Tumor Cells on PEDOT NanoVelcro Chips for RNA Biomarker Detection, Adv. HealthCare Mater. 6(X): In press. PMCID: PMC5803304
S. Sho, P. Winograd, S. Lee, S. Hou, T. G. Graeber, H.-R. Tseng, J.S. Tomlinson (2017) Precision Oncology Using a Limited Number of Cells: Optimization of Whole Genome Amplification Products for Sequencing Applications, BMC Cancer, 17, 457-470. PMCID: PMC5493892
S. Hou, M. Lin, J.-F. Chen, M. Song, Y. Zhu, Y.J. Jan, S. H. Chen, T.-H. Weng, D.-A. Ling, S.-F. Chen, T. Ro, A.-J. Liang, T. Lee, H. Jin, M. Li, L. Liu, Y. S. Hsiao, P. Chen, H. Yu, M.-S. Tsai, M. D. Pisarska, A. Chen, L.-C. Chen, H.-R. Tseng (2017) Imprinted NanoVelcro Microchips for Isolation and Characterization of Circulating Fetal Trophoblasts: Toward Noninvasive Prenatal Diagnostics, ACS Nano, 11(8): 8167-8177. PMCID: PMC5614709
R.L. Grossman, B. Abel, S. Angiuoli, J.C. Barrett, D. Bassett, K. Bramlett, G.M. Blumenthal, A. Carlsson, R. Cortese, J. DiGiovanna, B. Davis-Dusenbery, R. Dittamore, D.A. Eberhard, P. Febbo, M. Fitzsimons, Z. Flamig, J. Godsey, J. Goswami, A. Gruen, F.O. Guzman, J. Han , D. Hayes, J. Hicks, D. Holloway, D. Hovelson, J. Johnson, H. Juhl, R. Kalamegham, R. Kamal, Q. Kang, G.J. Kelloff, M. Klozenbuecher, A. Kolatkar, P. Kuhn, K. Langone, R. Leary, P. Loverso, H. Manmathan, A.M. Martin, J. Martini, D. Miller, M. Mitchell, T. Morgan, R. Mulpuri, T. Nguyen, G. Otto, A. Pathak, E. Peters, R. Philip, E. Posadas, D. Reese, M.G. Reese, D. Robinson, A.D. Rossi, H. Sakul, J. Schageman, S. Singh, H.I. Scher, K. Schmitt, A. Silvestro, J. Simmons, T. Simmons, J. Sislow, A. Talasaz, P. Tang, M. Tewari, S. Tomlins, H. Toukhy, H.-R. Tseng, M. Tuck, A. Tzou, J. Vinson, Y. Wang, W. Wells, A. Welsh, J. Wilbanks, J. Wolf, L. Young, J.S. Lee, L.C. Leiman (2017) Clin Pharmacol Ther. 101 (5): 589-592. PMCID: PMC5525192
J.F. Chen, Y.T. Lu, S. Cheng , H.-R. Tseng, R.A. Figlin, E.M. Posadas (2017) Circulating Tumor Cells in Prostate Cancer: Beyond Enumeration, Clin. Adv. Hematol. Oncol. 15(1): 63-73.
S. Cheng, J.-F. Chen, Y.-T. Lu, L. W.K. Chung, H.-R. Tseng, E.M. Posadas (2016) Applications of Circulating Tumor Cells for Prostate Cancer, Asian Journal of Urology, 3(4): 254-259. PMCID: PMC5730870
R. Wang, C.-Y. Chu, S. Mrdenovic, A.A. Annamalai, A.E. Hendifar, N. N. Nissen, J.S. Tomlinson, M. Lewis, N. Palanisamy, H.-R. Tseng, E.M. Posadas, S.J. Pandol, H.E. Zhau, L.W.K. Chung (2016) Cultured Circulating Tumor Cells and Their Derived Xenografts for Personalized Oncology, Asian Journal of Urology, 3(4): 240-253. PMCID: PMC5730836
S. Liu, Z. Tian, L. Zhang, S. Hou, S. Hu, J. Wu, Y. Jing, H. Sun, F. Yu, L. Zhao, R. Wang, H.-R. Tseng, H. E. Zhau, L.W. Chung, K. Wu, H. Wang, J.B. Wu, Y. Nie, C. Shao (2016) Combined Cell Surface Carbonic Anhydrase 9 and CD147 Antigens Enable High-Efficiency Capture of Circulating Tumor Cells in Clear Cell Renal Cell Carcinoma Patients, Oncotarget, 7(37):59877-59891. PMCID: PMC5312355
C. M. Court, J. S. Ankeny, S. Sho, S. Hou, Q. Li, C. Hsieh, M. Song, X. Liao, M. M. Rochefort, Z. Wainberg, T. Graeber, H.-R. Tseng, J. S. Tomlinson (2016) Reality of Single Circulating Tumor Cell Sequencing for Molecular Diagnostics in Pancreatic Cancer, J. Mol. Diagn. In press. PMCID: PMC5397706
J.-F. Chen, Y. Zhu, Y.-T. Lu, E. Hodara, S. Hou, V. G. Agopian, J. S. Tomlinson, E. M. Posadas, H.-R. Tseng (2016) Clinical Applications of NanoVelcro Rare-Cell Assays for Detection and Characterization of Circulating Tumor Cells, Theranostics, 6(9): 1425-1439. PMCID: PMC4924510
J. Ankeny, C. Court, S. Hou, Q. Li, M. Song, D. Wu, J.-F. Chen, T. Lee, M. Lin, S. Sho, M. Rochefort, M. Girgis, J. Yao, Z. Wainberg, V. Muthusamy, R. Watson, T. Donahue, O. Hines, H. Reber, T. Graeber, H.-R. Tseng, and J. Tomlinson (2016) Circulating Tumor Cells as a Biomarker for Diagnosis and Staging in Pancreatic Cancer, Br. J. Cancer, 114, 1367–1375. PMCID: PMC4984454
W. He, D. Xu, Z. Wang, X. Xiang, B. Tang, S. Li, M. Hou, Y. Zhang, J.-F Chen, M. Lin, L. Wang, S. Hou, H.-R. Tseng, M. Kuang, Z.-F. Ke (2016) Detecting ALK-Rearrangement of CTC Enriched by NanoVelcro Chip in Advanced NSCLC Patients, Oncotarget, 7: in press. PMCID: in process
L. Zhao, C. Tang, L. Xu, Z. Zhang, X. Li, H. Hu, S. Cheng, W. Zhou, M. Huang, A. Fong, B. Liu, H.-R. Tseng, H. Gao, Y. Liu, X. Fang (2016) Enhanced and Differential Capture of Circulating Tumor Cells from Lung Cancer Patients by Microfluidic Assays Using Aptamer Cocktail, Small, 12(8):1072-81. PMCID: PMC4893320
R. Jiang, Y.-T. Lu, H. Ho, B. Li, J.-F. Chen, M. Lin, F. Li, K. Wu, H. Wu, J. Lichterman, Hao. Wan, C.-L. Lu, W. OuYang, M. Ni, L. Wang, G. Li, T. Lee, X. Zhang, J. Yang, M. Rettig, L.W.K. Chung, H. Yang, K.-C. Li, Y. Hou, H.-R. Tseng, S. Hou, X. Xu, J. Wang, E.M. Posadas (2015) A Comparison of Isolated Circulating Tumor Cells and Tissue Biopsies Using Whole-Genome Sequencing in Prostate Cancer, Oncotarget, 6(42): 44781-44793. PMCID: PMC4792591
C.M. Court, J.S. Ankeny, S. Hou, H.-R. Tseng, J.S Tomlinson (2015) Improving Pancreatic Cancer Diagnosis Using Circulating Tumor Cells, Prospects for Staging and Single-Cell Analysis, Expert Review of Molecular Diagnostics, 15(11): 1491-1504. PMCID: PMC4893319
J.-F. Chen, H. Ho, J. Lichterman, Y.-T. Lu, Y. Zhang, M. A. Garcia, S.-F. Chen, A.-J. Liang, S. Hou, R. S. Ahmed, D. J. Luthringer, J. Huang, K.-C. Li, L. W.K. Chung, Z. Ke, H.-R. Tseng , E. M. Posadas (2015) Subclassification of Prostate Cancer Circulating Tumor Cells by Nuclear Size Reveals Very Small Nuclear Circulating Tumor Cells in Patients with Visceral Metastases, Cancer, 121: 3240–3251. PMCID: PMC4560974
Z. Ke, M. Lin, J.-F. Chen, J.-S. Choi, Y. Zhang, A. Fong, A.-J. Liang, S.-F. Chen, Q. Li, M. A. Garcia, T. Lee, M. Song, H.-A. Lin, H. Zhao, S.-C. Luo, S. Hou, H. Yu, H.-R. Tseng (2015) Programming Thermoresponsiveness of NanoVelcro Substrates Enables Effective Purification of Circulating Tumor Cells in Lung Cancer Patients, ACS Nano. 9: 62-70. PMCID: PMC4310634
M. Lin, J.-F. Chen, Y.-T. Lu, Y. Zhang, J. Song, S. Hou, Z. Ke, H.-R. Tseng (2014) Nanostructures-Embedded Microchips for Detection, Isolation, and Characterization of Circulating Tumor Cells, Acc. Chem. Res. 47: 2941-2950. PMCID: PMC4204926
Y.-S. Hsiao, S.-C. Luo, S. Hou, B. Zhu, J. Sekine, C.-W. Kuo, D.-Y. Chueh, H. Yu, H.-R. Tseng, and P. Chen (2014) 3D Bioelectronic Interface: Capturing Circulating Tumor Cells onto Conducting Polymer-Based Micro/Nanorod Arrays with Chemical and Topographical Control, Small, 10: 3012–3017. PMCID: PMC4125486
Y.-T. Lu, L. Zhao, Q. Shen, M. A. Garcia, D. Wu, S. Hou, M. Song, X. Xu, W.-H. OuYang, Z. Luo, T. Lee, .X. Xuan, J. Huang, L. W. K. Chung, M. Rettig, H.-R. Tseng, C. Shao, E. M. Posadas (2013) NanoVelcro Chip for CTC Enumeration in Prostate Cancer Patients, Methods, 64:144-152. PMCID: PMC3834112
L. Zhao, Y.-T. Lu, F. Li, K. Wu, S. Hou, J. Yu, Q. Shen, D. Wu, M. Song, W.-H. OuYang, Z. Luo, T. Lee, C. Shao, X. Xu, M. A. Garcia, L. W. K. Chung, M. Rettig, H.-R. Tseng, E. M. Posadas (2013) High-Purity Prostate Circulating Tumor Cell Isolation by a Polymer Nanofiber-Embedded Microchip for Whole Exome Sequencing, Adv. Mater. 25: 2897-2902. PMCID: PMC3875622(Internal Cover Highlight)
Q. Shen, L. Xu, L. Zhao, D. Wu, Y. Fan, Y. Zhou, W.-H. OuYang, X. Xu, Z. Zhang, T. Lee, B. Xiong, S. Hou, H.-R. Tseng, X. Fang (2013) Specific Capture and Release of Circulating Tumor Cells Using Aptamer Modified Nanosubstrates, Adv. Mater. 25: 2368–2373. PMCID: PMC3786685
S. Hou, Q. Shen, L. Zhao, J. Yu, C. Ng, X. Kong, D. Wu, M. Song, X. Shi, X. Xu, W.-H. OuYang, R. He, X.-Z. Zhao, B. Xiong, T. Lee, C. Brunicardi, M. A. Garcia, A. Ribas, R. S. Lo, H.-R. Tseng (2013) Polymer Nanofiber-Embedded Microchips for Detection, Isolation, and Molecular Analysis of Single Circulating Melanoma Cells. Angew. Chem. Int. Ed. 52: 3379–3383. PMCID: PMC3807678 (Internal Cover Highlight)
S. Hou, H. Zhao, L. Zhao, Q. Shen, K. S. Wei, D. Y. Suh, A. Nakao, M. A. Garcia, M. Song, T. Lee, B. Xiong, S.-C. Luo, H.-R. Tseng, H. Yu (2013) Capture and Stimulated Release of Circulating Tumor Cells on Polymer Grafted Silicon Nanostructures. Adv. Mater. 25: 1547–1551. PMCID: PMC3786692 (Internal Cover Highlight)
N. Zhang, Y. Deng, B. Cheng, L. Zhao, Q. Tai, L. Hong, Q. Shen, K. Liu, S. Guo, H.-R. Tseng, B. Xiong, X.-Z. Zhao (2012) Electrospun TiO2 Nanofiber-Based Cell Capture Assay for Detecting Circulating Tumor Cells from Colorectal and Gastric Cancer Patients. Adv. Mater. 24: 2756-2760.
J. Sekine, S.-C. Luo, S. Wang, B. Zhu, H.-R. Tseng and H.-H. Yu (2011) Functionalized Conducting Polymer Nanodots for Enhanced Cell Capturing: The Synergistic Effect of Capture Agents and Nanostructures. Adv. Mater. 23: 4778-4792.
S. Wang, K. Liu, J. Liu, Z. T.-F. Yu, E. K. Lee, X. Xu, J. Reiss, T. Lee, L. W. K. Chung, J. Huang, M. Rettig, D. Seligson, K. N. Duraiswamy, C. K.-F. Shen and H.-R. Tseng (2011) Highly Efficient Capture of Circulating Tumor Cells Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers. Angew. Chem. Int. Ed. 50: 3084-3088. (Featured on the Cover) PMCID: PMC3085082
J. Sun, M. Masterman-Smith, N. A. Graham, J. Jiao, J. Mottahedeh, M. Ohashi, J. DeJesus, D. R. Laks, E. Panosyan, J. Park, K. Kamei, K.-B. Lee, H. Wang, Z. T.-F. Yu, Y.-T. Lu, S. Hou, K. Li, M. Liu, N. Zhang, S. Wang, B. Angenieux, E. Samuels, D. Williams, V. Kankatit, D. Nathanson, M. van Dam, M. Phelps, L. Liau, P. S. Mischel, J. A. Lazareff, H. I. Kornblum, H. Wu, W. H. Yong, T. G. Graeber, H.-R. Tseng (2010) A Microfluidic Platform for Systems Pathology: Multiparameter Single-Cell Signaling Measurements of Clinical Brain Tumor Specimens. Cancer Research 70: 6128-6138. PMCID: PMC3163840
S.Wang, H. Wang, J. Jiao, K.-J. Chen, G. E. Owens, K. Kamei, J. Sun, D. J. Sherman, C. P. Behrenbruch, H. Wu, H.-R. Tseng (2009) Three-Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells. Angew. Chem. Int. Ed. 48: 8970-8973. PMCID: PMC2878179